Tom Knight and Scott Elstone have left Derbyshire by mutual consent.
Both players, who are in the final year of their contracts, have been released from their current deals and leave the Club with immediate effect.
Knight, a former England Under-19 international, made 43 first-team appearances for the county since making his debut in 2011.
Elstone, who joined Derbyshire in 2014, featured in 14 first-class fixtures for the Club, scoring 452 runs, with a top score of 103 not out versus Glamorgan in 2015. In total, he made 49 appearances across all formats.
Head Coach, John Sadler said: “Tom and Scott are both hard working individuals who always gave their all, with bat, ball and in the field, when representing the Club.
“We wish them both all the best for the future.”