Luis Reece claimed two wickets in his first two overs as Derbyshire took eight wickets on Day Two, leaving Loughborough MCCU on 351-9 going into the final day.
Reece’s two wickets in four deliveries before tea boosted the Derbyshire seam attack, which took eight wickets in the day and four in the final session.
Loughborough began Day Two on 48-1, 315 runs behind Derbyshire’s first innings declaration of 363-8.
Tom Milnes took his second wicket of the innings in the day’s third over, Sam Evans caught behind by Gary Wilson for 22. It was Wilson’s second catch of the game to add to his 106 runs in his first innings for Derbyshire.
James Bracey and new batsman Nitish Kumar then put on a 94-run partnership for the third wicket, which was broken by Tom Taylor, returning to bowl his second spell.
The Derbyshire seamer had Kumar caught by Reece for 57, bringing wicketkeeper Robbie White to the crease.
The pair put on 109 for the fourth wicket, Bracey passing his century from 177 balls, including 17 fours. The opener was out soon after, Reece claiming a wicket in his first over, caught by Daryn Smit for 104.
The all-rounder then had his second wicket in four balls, dismissing White, who was caught by Smit for 62. Loughborough fell from 260-3 to 261-5 and the left-armer had bowled two overs, one maiden and taken two wickets for just three runs.
The two new batsmen, Basil Akram and Joe Kendall, put on 39 before Will Davis broke the partnership. The paceman removed Akram for 21 who he was caught by Smit, the all-rounder’s third catch of the innings.
Derbyshire then claimed three wickets in as many overs, looking to quickly wrap up the Loughborough innings. First Kendall was caught behind by Wilson off Palladino for 29, the experienced bowler claiming his first wicket of 2017.
Taylor then produced a wicket maiden the following over, bowling Bobbie Gamble for one as Derbyshire looked to wrap up the innings.
Palladino then removed Adam Tillcock for 29, caught by Wayne Madsen.
Sam Cook and Ben Ladd-Gibbon batted out the remainder of the session and Loughborough will resume on the final morning on 351-9, trailing by 12.
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