South Africa need a just further seven wickets on the fifth day for a consolation victory in the final Test after reducing England to 52-3.
Needing 382 to win, or to survive four sessions to draw, England lost Alex Hales, Alastair Cook and Nick Compton cheaply inside 10 overs in Centurion.
20-year-old seamer, Kagiso Rabada, who claimed 7-112 in the first innings, took a further two wickets – Hales for one and Compton for six – either side of Cook being caught and bowled by Morne Morkel on five.
Earlier, the hosts had declared on 248-5, thanks to another big score by former Derbyshire man, Hashim Amla, who hit 96 to follow up his century in the first innings and increase his chances of finishing as top-scorer in the four-match series.
Amla was helped by another enterprising knock by Temba Bavuma who finished unbeaten on 78 as the Proteas set England an unlikely 382 to win.
No side has chased more than 251 to win at SuperSport Park and England go into the final day needing another 330 runs to win with seven wickets in hand.
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