Ben Slater top-scored with 68, but Derbyshire slipped to a 95-run defeat to Durham on Day Four at Emirates Riverside.
The opener rallied in a Derbyshire innings which stuttered early on, and although he looked in good touch for his fourth half-century of the campaign, no other batsman was able to score above 29.
Chris Rushworth claimed five for the hosts as Durham took wickets at regular intervals to bowl Derbyshire out for 172 and seal a 95-run victory.
Vitality Blast is back! Derbyshire Falcons host seven Twenty20 games this July and August. Purchase your tickets in advance and save from £4. Buy online or call 01332 388 101.
[twentyticket]