Tom Wood hit 82 and there were two other half-centuries for Derbyshire as the hosts posted 290 and had Worcestershire 40-1 at the end of Day One at Belper Meadows.
The Derbyshire openers put on 103 for the first wicket and Wood batted well for his 82 after coming in at four. But three wickets each for Ben Twohig and Dillon Pennington restricted the hosts to 290 in their first innings of the Second XI Championship match.
James Kettleborough made 65 an fellow opener Harvey Hosein hit 52 as Derbyshire got off to a good start after winning the toss and electing to bat.
A strong Worcestershire bowling attack, led by Pennington and Twohig, fought back to take five wickets for 85 runs as Derbyshire slipped to 188-5.
Aiden Wheeler made 26 and Hamidullah Qadri added 16 as Derbyshire were eventually all out for 290.
Olly Westbury batted well for his 18 not out, but Wheeler (1-22) struck early to remove Tom Fell (18) and leave Worcestershire 40-1 heading into Day Two.
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