The Second XI T20 fixture against Leicestershire on Thursday 1 August will now be played at The Fischer County Ground.
The first of two matches, which were due to be played at Rugby School, will start at 11:30 am, with the second match beginning at 3pm.
The Second XI have been in good form, having picked up victories over Warwickshire, Nottinghamshire, Lancashire and Yorkshire in recent weeks.
Vitality Blast is back! Derbyshire host a hat-trick of Twenty20 matches at The Pattonair County Ground in August. Buy in advance to save. Call 01332 388 101 or buy online.