Aneurin Donald scored another rapid half-century, but Derbyshire fell just short of a mammoth chase of 238 at The County Ground, Northampton.
Back from Test duty with South Africa, Breetzke adjusted instantly to the change of format, setting the pace with nine fours and five sixes in a partnership of 125 in 10.4 overs with skipper David Willey who made 53 off 33 deliveries (6 fours, 2 sixes).
With Saif Zaib also making an unbeaten 53 from 20 balls (3 fours, 4 sixes), Northamptonshire finished with 237 for four, equalling their highest ever T20 score scored away against Yorkshire earlier this season.
Derbyshire looked on course to chase down the target and post their highest ever T20 total. In a display of ferocious hitting, Aneurin Donald smashed 71 off just 22 balls (8 fours, 6 sixes) in a blistering opening stand worth 112 in just 7.4 overs with Caleb Jewell (39). But Australian leg-spinner Lloyd Pope made the crucial double breakthrough, removing both Donald and Jewell in his opening over. George Scrimshaw then struck twice in his second over to further arrest Derbyshire’s hopes.
The match saw the highest aggregate score between these two sides in T20 cricket.
Earlier, Allah Ghazanfar trapped Ricardo Vasconcelos lbw and almost picked up Breetzke but shelled a simple return catch. The South African responded by pulling Aitchison for six and taking three consecutive boundaries off Zak Chappell as Northamptonshire finished the powerplay on 51 for one.
Breetzke progressed to his half-century off just 24 deliveries, pummelling Alex Thomson through extra cover before dispatching consecutive sixes.
Willey got into the groove too, hitting Aitchison over his head before running a single to bring up the Steelbacks’ 100 at the end of the tenth over. Breetzke then flat-batted Ghazanfar straight for six to bring up the 100 partnership off 54 balls. Later in the over, Derbyshire incurred five penalty runs for a Level 2 disciplinary offence when Ghazanfar threw the ball in what was deemed an inappropriate or dangerous manner.
Willey hit Samit Patel for consecutive straight sixes before he was caught in the deep. Such was their rate of acceleration, he and Breetzke had added 81 in the previous six overs.
Zaib made a blistering start, clubbing Patel down the ground and sweeping for six. Meanwhile Breetzke paddled Aitchison round the corner for a huge six, but fell next ball, edging behind. The 200 came up courtesy of four overthrows, while Zaib continued his assault.
Donald struck five boundaries off Willey’s opening over in the chase. He attacked Scrimshaw too, the former Derbyshire man leaking 24 off his opening over, Donald sending one ball sailing over fine leg for six, Derbyshire reaching 50 off just 19 balls.
Jewell went after left-arm spinner Zaib too, sweeping him for six. But Northamptonshire missed a tough chance to remove Donald on 41 when keeper Lewis McManus slipped attempting a catch off a skier.
Donald pulled Willey for six to close out the powerplay at 85 without loss before bludgeoning consecutive sixes off Luke Procter to reach his half-century and Derbyshire’s 100.
But Pope’s double-wicket strike lifted the spirits of the home fans, as first Jewell was trapped lbw before Donald was caught behind chasing a wide one. Scrimshaw then struck twice in the 11th over, having Ross Whiteley caught at mid-on and bowling Martin Andersson.
Wayne Masden (29) and Harry Came (35*) continued to attack before Masden holed out in the deep off Procter. While Northamptonshire shelled other chances, McManus made no mistake in the final over, catching Patel off a skier, off Procter’s bowling.